Relationship between environmental carcinogens and EGFR targeting anti-tumor agents in head and neck cancer.
نویسنده
چکیده
منابع مشابه
Molecular targeting of ultrasonographic contrast agent for detection of head and neck squamous cell carcinoma.
OBJECTIVE To investigate the feasibility of ultrasonographic (US) imaging of head and neck cancer with targeted contrast agents both in vitro and in vivo. We hypothesize that conjugation of microbubble contrast agent to tumor-specific antibodies may improve US detection of head and neck squamous cell carcinoma (HNSCC). DESIGN Preclinical blinded assessment of anti-EGFR and anti-CD147 microbub...
متن کاملThe impact of timing of EGFR and IGF-1R inhibition for sensitizing head and neck cancer to radiation.
BACKGROUND Targeting the epidermal growth factor receptor (EGFR) improved radiotherapy outcome by 10-15% in head and neck tumors (HNSCC). We tested the therapeutic benefits of co-targeting EGFR and insulin-like growth factor-1 receptor (IGF-1R) to further enhance tumor response to radiation. MATERIALS AND METHODS Mice bearing FaDu tumor xenografts were treated with ganitumab (previously known...
متن کاملImproving Response Rates to EGFR-Targeted Therapies for Head and Neck Squamous Cell Carcinoma: Candidate Predictive Biomarkers and Combination Treatment with Src Inhibitors
The epidermal growth factor receptor- (EGFR-) directed antibody, cetuximab, was FDA-approved for the treatment of squamous cell carcinoma of the head and neck (SCCHN) in 2006. Additional EGFR-targeting agents in clinical development for SCCHN include other EGFR-directed antibodies, tyrosine kinase inhibitors and antisense DNA. Although the majority of SCCHN overexpress EGFR, SCCHN clinical resp...
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BACKGROUND Anti-epidermal growth factor receptor (EGFR) therapies are effective in head and neck carcinoma. A meta-analysis was performed to assess their efficacy and safety in advanced head and neck carcinoma. METHODS Six trials randomizing 2257 patients with recurrent/metastatic head and neck carcinoma for chemotherapy or best supportive care with or without anti-EGFR therapies were identif...
متن کاملInsulin-like growth factor receptor as a therapeutic target in head and neck cancer.
PURPOSE Insulin-like growth factor type I receptor (IGF-IR) plays critical roles in epithelial cancer cell development, proliferation, motility, and survival, and new therapeutic agents targeting IGF-IR are in development. Another receptor tyrosine kinase, the epidermal growth factor receptor (EGFR), is an established therapeutic target in head and neck cancer and IGF-IR/EGFR heterodimerization...
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عنوان ژورنال:
- Journal of the Chinese Medical Association : JCMA
دوره 73 9 شماره
صفحات -
تاریخ انتشار 2010